3 years ago

Edge-to-edge mitral valve repair: solid data and a prosperous future

In recent years, transcatheter edge-to-edge mitral valve repair (E2E-MVR) using the mitral clip approach (MitraClip, Abbott Vascular, Menlo Park, California, USA) has evolved as the predominant alternative non-surgical treatment option for patients with symptomatic mitral regurgitation (MR) who were judged inoperable by a heart team. By now, more than 45 000 patients have been treated with this approach, demonstrating a wide acceptance for this interventional treatment.

MR is classified on the basis of the underlying aetiology as primary (degenerative) or secondary (functional) that constitute markedly different diseases. In patients with primary MR, the mitral valve apparatus per se is diseased and left ventricular ejection fraction (LV-EF) is mostly preserved (mean LV-EF of 58% in Chiarito et al’s Heart manuscript).1 The Endovascular Valve Edge-to-Edge Repair Study (EVEREST) II2—which included predominantly patients with primary MR (in 73% of randomised patients)—E2E-MVR did not reduce MR as effectively as surgical mitral valve...

Publisher URL: http://heart.bmj.com/cgi/content/short/104/4/280

DOI: 10.1136/heartjnl-2017-311922

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