Nature Communications
Nature Communications
4 years ago

Antigen-specific CD8+ T cell feedback activates NLRP3 inflammasome in antigen-presenting cells through perforin

Antigen-specific CD8+ T cell feedback activates NLRP3 inflammasome in antigen-presenting cells through perforin
Mengtao Cao, Tao Yang, Yin Huang, Xinyang Song, Youcun Qian, Yongqin Li, Yikun Yao, Feng Wang, Yufang Shi, Xing Fan, Lilin Ye, Nan Shen, Siyuan Chen, Xiaoxia Li
The connection between innate and adaptive immunity is best exemplified by antigen presentation. Although antigen-presenting cells (APCs) are required for antigen receptor-mediated T-cell activation, how T-cells feedback to APCs to sustain an antigen-specific immune response is not completely clear. Here we show that CD8+ T-cell (also called cytotoxic T lymphocytes, CTL) feedback activates the NLRP3 inflammasome in APCs in an antigen-dependent manner to promote IL-1β maturation. Perforin from antigen-specific CTLs is required for NLRP3 inflammasome activation in APCs. Furthermore, such activation of NLRP3 inflammasome contributes to the induction of antigen-specific antitumour immunity and pathogenesis of graft-versus-host diseases. Our study reveals a positive feedback loop between antigen-specific CTLs and APC to amplify adaptive immunity.

Publisher URL: http://www.nature.com/articles/ncomms15402

DOI: 10.1038/ncomms15402

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