Crystal Growth & Design
Crystal Growth & Design
5 years ago

Interplay between Thermodynamics and Kinetics on Polymorphic Appearance in the Solution Crystallization of an Enantiotropic System, Gestodene

Interplay between Thermodynamics and Kinetics on Polymorphic Appearance in the Solution Crystallization of an Enantiotropic System, Gestodene
Li-yu Wang, Xiao-yu Zhao, Yan-fei Wang, Wei Du, Liang Zhu, Zuo-liang Sha, Li-bin Yang
The polymorph of gestodene crystallizing from the cooling crystallization in solution is difficult to control due to the concomitant appearance of forms I and II. In this work, a systematic design of a crystallization temperature and initial supersaturation coupled controlled crystallization system was performed to control the polymorphism. The interplay between thermodynamics and kinetics on the polymorphic outcome was discussed.

Publisher URL: http://dx.doi.org/10.1021/acs.cgd.7b00335

DOI: 10.1021/acs.cgd.7b00335

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