3 years ago

Inside Front Cover: Features of lineage-specific hematopoietic metabolism revealed by mitochondrial proteomics

Inside Front Cover: Features of lineage-specific hematopoietic metabolism revealed by mitochondrial proteomics
Anthony Whetton, Claudia Billing, Uta Ceglarek, Christian Böhme, Michael Walker, Dietger Niederwieser, Michael Cross, Nicole Noack
DOI: 10.1002/pmic.201700053The daily production of more than 1011 erythroid (red) and myeloid (white) cells places a large anabolic demand on small regions of bone marrow. Billing et al. use a scalable in vitro differentiation system to generate large numbers of erythroid and myeloid cells at various stages of differentiation and investigate the proteome of purified mitochondria using iTRAQ LC-MS/MS. Their results reveal lineage-specific shifts consistent with metabolic compartmentalization within the marrow. For more details, see the research article by Billing et al., article number 1700053.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/pmic.201770122

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