Mechanochemical Synthesis of Phosphazane-Based Frameworks

5 years ago

Mechanochemical Synthesis of Phosphazane-Based Frameworks

Ying Sim, Yongxin Li, Felipe García, Rakesh Ganguly, Yan X. Shi

Mechanochemistry is emerging as a powerful solvent-free approach to chemical synthesis, having been applied to metal oxides, pharmaceutical materials, organic compounds and to a lesser extent, coordination complex synthesis. Notably, examples of applications of mechanochemical methodologies in the synthesis of main-group compounds are few and far between. Herein, we demonstrate that ball milling enabled the solvent-free synthesis of a range of phosphazane frameworks with a broad substrate scope, yielding seven new acyclic and macrocyclic species. The strength of this methodology is highlighted by a fast, selective and high-conversion product generation from poorly soluble starting materials, thereby demonstrating mechanochemistry as a real alternative to solution-based methods in synthetic main-group chemistry. Goes round and round: Ball milling enabled the solvent-free synthesis of a range of phosphazane-based frameworks with a broad substrate scope (see figure, tBu=tert-butyl). Seven new acyclic and macrocyclic species were obtained and characterised. This study therefore, demonstrates that mechanochemistry is a real alternative to solution-based methods in synthetic main-group chemistry.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/chem.201701619