3 years ago

Continuous Flow Synthesis of Urea-Containing Compound Libraries Based on the Piperidin-4-one Scaffold

Continuous Flow Synthesis of Urea-Containing Compound Libraries Based on the Piperidin-4-one Scaffold
Floris P. J. T. Rutjes, Alejandra Riesco-Domínguez, Daniel Blanco-Ania
The advantages of performing reactions in continuous flow vs. the classic batch processes render flow chemistry a suitable technique for library synthesis. Inspired by our recent work to create fluorine-containing nitrogen heterocycles and by the potential of the urea group in drug design, we herewith describe the combination of both aspects in the continuous flow synthesis of two libraries of urea derivatives based on the piperidin-4-one scaffold. Two libraries of urea compounds based on the piperidin-4-one scaffold have been developed in continuous flow and twenty drug-like compounds were synthesized in moderate to high yields.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/ejoc.201701539

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