3 years ago

Hydrozirconation of C=X Functionalities with Schwartz's Reagent

Hydrozirconation of C=X Functionalities with Schwartz's Reagent
Sebastian Stecko, Michał M. Więcław
Hydrozirconation of various C=X functionalities with Schwartz's reagent is a powerful method for preparing functionalized organic molecules, for instance aldehydes, amines, and amides. The reactions of [Cp2Zr(H)Cl] with amides, lactams, nitriles or isocyanates proceed under mild conditions. These transformations are remarkably chemoselective as Schwartz's reagent is compatible with various functional groups, including electrophilic functionalities such as ester, nitrile, nitro, and halogens. This compatibility enables many hydrozirconation reactions to be combined with other synthetic methods, and enables performing the reactions in a one-pot fashion as multicomponent processes.This Microreview covers the reactions of [Cp2Zr(H)Cl] with C=X functionalities, such as amides, lactams, nitriles or isocyanates, as a method for chemoselective preparation of functionalized organic molecules, for instance aldehydes, amines, and amides.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/ejoc.201701537

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