3 years ago

Front Cover: Synthesis and Applicability of Base-Discriminating DNA-Triplex-Forming 19F NMR Probes (Eur. J. Org. Chem. /2018)

Front Cover: Synthesis and Applicability of Base-Discriminating DNA-Triplex-Forming 19F NMR Probes (Eur. J. Org. Chem. /2018)
Naresh Bhuma, Ville Tähtinen, Pasi Virta
The Front Cover shows triplex-forming 19F NMR probes that recognize nucleobase content in the pyrimidine-rich strand of double-helical DNA targets. The obtained 19F NMR resonances are sensitive to the base content, and unique 19F NMR-spectral fingerprints could be obtained. The idea of the probes may find application in studies in which the goal is to simultaneously detect changes of local environments (e.g., upon binding of nucleobase-specific ligands) in structurally resembling double-helical stretches. More information can be found in the Full Paper by N. Bhuma, V. Tähtinen, and P. Virta.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/ejoc.201800052

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