3 years ago

99mTc-labeled rHuEpo for imaging of the erythropoietin receptor in tumors

Rui Liang, Chunlei Han, Xiaoqing Zhuang, Pengfei Yang, Juan Li, Ruilong Sheng, Joseph M. Kinsella, Yingqin Jia, Qian Zhao, Dan Zhao
To analyze erythropoietin receptor (EpoR) status in tumors, recombinant human erythropoietin (rHuEpo) was labeled with 99mTc by 99mTc-centered one-pot synthesis, resulting in high radiochemical purity, stability and biological activity. Both in vitro cell culture experiments and biodistribution studies of normal rats demonstrated successful EpoR targeting. The biodistribution of labeled rHuEpo in a NCI-H1975 xenograft model showed tumor accumulation (tumor-to-muscle ratio: 4.27±1.77), confirming the expression of active EpoR in tumors. Thus, as a novel SPECT tracer for the imaging of EpoR expression in vivo, 99mTc-rHuEpo is effective for exploring the role of EpoR in cancer growth, metastasis and angiogenesis.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/jlcr.3586

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