3 years ago

Effects of age and diet on glucose and insulin dynamics in the horse

H. C. Schott, R. J. Geor, L. J. McCutcheon, J. L. Rapson, P. A. Harris, B. D. Nielsen
Background Age and diet may affect insulin sensitivity (SI) but these factors have received limited investigation in horses. Objectives To measure minimal model parameters during an insulin-modified frequently sampled intravenous glucose tolerance test (FSIGTT) after adaptation to a forage only diet (HAY) or forage supplemented with either starch/sugar rich (SS) or oil/fibre rich (FF) concentrate feeds; and to assess glucose and insulin responses to a standardised meal challenge (SMC, 4 g/kg BW of SS) after diet adaptation in adult and aged mares. Study design Latin square design with 8 adult (5-12 years) and 9 aged (>19 years) healthy mares. Methods Diets were fed for 6 weeks and the FSIGTT and SMC were performed after 31-32 and 41 days on each diet, respectively. Data were analysed by a mixed ANOVA for repeated measures. Results Acute insulin response to glucose (AIRg) was greater and SI was lower in aged horses, compared to adults, regardless of diet. Both AIRg and SI were greater in aged mares after adaptation to SS, as compared to HAY. Similar trends, although not statistically significant, were observed after adaptation to SS in adult mares. Peak insulin concentration and area under the insulin vs. time curve during the SMC were greater in aged than adult mares with all diets. Further, area under the glucose vs. time curve was lower after adaptation to SS, when compared to other diets, in both groups. Main limitations Transient weight loss occurred at the beginning of the study and only one sex was included. Incomplete ingestion of the SMC by four mares was another limitation. Conclusions Insulin responses to intravenous and enteral nonstructural carbohydrate challenge increase with age in healthy horses, regardless of diet fed. This article is protected by copyright. All rights reserved.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1111/evj.12812

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