3 years ago

Difluoromethylation of parent azoles

Difluoromethylation of parent azoles
The method for difluoromethylation of parent azoles, namely pyrrole, 1,2,3-triazole, 1,2,4-triazole and tetrazole was developed. Difluorometylation of pyrrole and 1,2,3-triazole was performed by action of chlorodifluoromethane. Sodium chlorodifluoroacetate was used as a difluoromethylation agent for 1,2,4-triazole and tetrazole. N-Difluoromethyl derivatives of pyrrole, 1,2,3- and 1,2,4- triazoles were synthesized in moderate to good yields in a multigram scale. N-difluoromethyltetrazole was obtained in a low yield.

Publisher URL: www.sciencedirect.com/science

DOI: S0022113917304098

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