Chemistry - A European Journal
Chemistry - A European Journal
5 years ago

Activatable Near-Infrared Probe for Fluorescence Imaging of γ-Glutamyl Transpeptidase in Tumor Cells and In Vivo

Activatable Near-Infrared Probe for Fluorescence Imaging of γ-Glutamyl Transpeptidase in Tumor Cells and In Vivo
Zhengyang Zhou, Deju Ye, Jian He, Runqi Yan, Hua Shi, Zhiliang Luo, Changge Ji, Guanfu Duan, Hong-Yuan Chen, Ruibing An, Liandong Feng
An activatable near-infrared probe was developed by linking of a γ-glutamyl transpeptidase (GGT)-recognitive substrate, and a near infrared (NIR) fluorophore with a self-immolative linker. The probe was stable and could generate significant turn-on fluorescence in response to GGT. The probe was used for the real-time imaging of GGT activity and screening of GGT inhibitors both in live tumor cells and mice, allowing for the study and diagnosis of GGT-related diseases. More information can be found in the Full Paper by D. Ye et al. (DOI: 10.1002/chem.201702210).

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/chem.201703472

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