Organic Letters
Organic Letters
5 years ago

Cobalt-Catalyzed Cross-Dehydrogenative Coupling Reaction between Unactivated C(sp2)–H and C(sp3)–H Bonds

Cobalt-Catalyzed Cross-Dehydrogenative Coupling Reaction between Unactivated C(sp2)–H and C(sp3)–H Bonds
Guigen Li, Weipeng Hu, Qun Li, Hongjian Lu, Renjian Hu
Catalytic oxidative cross-dehydrogenative coupling between unactivated C(sp2)–H and C(sp3)–H bonds is achieved by the cobalt-catalyzed o-alkylation reaction of aromatic carboxamides containing (pyridin-2-yl)isopropyl amine (PIP–NH2) as a N,N-bidentate directing group. Many different C(sp3)–H bonds in alkanes, toluene derivatives and even in the α-position of ethers and thioethers can be used as coupling partners. This method has a broad substrate scope and the tolerance of various functional groups.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b02316

DOI: 10.1021/acs.orglett.7b02316

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