Organic Letters
Organic Letters
5 years ago

Synthesis and N-Methyl-d-aspartate (NMDA) Receptor Activity of Ketamine Metabolites

Synthesis and N-Methyl-d-aspartate (NMDA) Receptor Activity of Ketamine Metabolites
Panos Zanos, Carlos A. Zarate, Todd Gould, Ruin Moaddel, Craig J. Thomas, Patrick J. Morris, Curtis E. Moore
Ketamine is rapidly metabolized in the human body to a variety of metabolites, including the hydroxynorketamines. At least two hydroxynorketamines have significant antidepressant action in rodent models, with limited action against the N-methyl-d-aspartate (NMDA) receptor. The synthesis of 12 hydroxynorketamines and their binding affinity to the NMDA receptor is presented here.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b02177

DOI: 10.1021/acs.orglett.7b02177

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