bioRxiv Biochemistry
bioRxiv Biochemistry
5 years ago

Swapping Of Transmembrane Domains In The Epithelial Calcium Channel TRPV6

Sobolevsky, K., Singh, A. I., A. K., Saotome
Tetrameric ion channels have either swapped or non-swapped arrangements of the S1-S4 and pore domains. Here we show that mutations in the transmembrane domain of TRPV6 can result in conversion from a domain-swapped to non-swapped fold. These results reveal structural determinants of domainswapping and raise the possibility that a single ion channel subtype can fold into either arrangement in vivo, affecting its function in normal or disease states.

Publisher URL: http://biorxiv.org/cgi/content/short/141523v1

DOI: 10.1101/141523

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