3 years ago

Research on Liebeskind-Srogl coupling/intramolecular Diels-Alder reaction cascade

Research on Liebeskind-Srogl coupling/intramolecular Diels-Alder reaction cascade
The Liebeskind-Srogl coupling/intramolecular Diels-Alder (IMDA) reaction cascade that stereoselectively affords a tricarbocyclic compound with a trans-trans-cis fused ring system including an all-carbon quaternary stereogenic center at the ring junction is described. The cascade reactions proceed quickly and stereoselectively afford the products within 2 h at room temperature in the presence of a suitable thioester. The developed protocol as well as the prepared chiral compounds are useful for the enantioselective total synthesis of terpenoids with the trans-trans-cis fused ring system.

Publisher URL: www.sciencedirect.com/science

DOI: S0040403918300807

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