3 years ago

The fungal pathogen Magnaporthe oryzae suppresses innate immunity by modulating a host potassium channel

Ruyi Wang, Guo-Liang Wang, Wei Wu, Xuetao Shi, Yi Wang, Chongyang Zhang, Feng He, Yuese Ning, Ting Zhang, Yu Long, Zeyun Hao
Potassium (K+) is required by plants for growth and development, and also contributes to immunity against pathogens. However, it has not been established whether pathogens modulate host K+ signaling pathways to enhance virulence and subvert host immunity. Here, we show that the effector protein AvrPiz-t from the rice blast pathogen Magnaporthe oryzae targets a K+ channel to subvert plant immunity. AvrPiz-t interacts with the rice plasma-membrane-localized K+ channel protein OsAKT1 and specifically suppresses the OsAKT1-mediated K+ currents. Genetic and phenotypic analyses show that loss of OsAKT1 leads to decreased K+ content and reduced resistance against M. oryzae. Strikingly, AvrPiz-t interferes with the association of OsAKT1 with its upstream regulator, the cytoplasmic kinase OsCIPK23, which also plays a positive role in K+ absorption and resistance to M. oryzae. Furthermore, we show a direct correlation between blast disease resistance and external K+ status in rice plants. Together, our data present a novel mechanism by which a pathogen suppresses plant host immunity by modulating a host K+ channel.

Publisher URL: http://journals.plos.org/plospathogens/article

DOI: 10.1371/journal.ppat.1006878

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