Journal of Organic Chemistry
Journal of Organic Chemistry
5 years ago

Substrate-Controlled Selectivity Switch in a Three-Component Reaction: A Ag-Catalyzed Strategy for the Synthesis of Functionalized Imidazoles

Substrate-Controlled Selectivity Switch in a Three-Component Reaction: A Ag-Catalyzed Strategy for the Synthesis of Functionalized Imidazoles
Hua Cao, Lijuan Zhang, Weixin Chen, Enming Wang, Changcheng Wang, Yuanheng Wu, Haiying Zhan
An efficient Ag-catalyzed three-component reaction of amidines, ynals, and alcohols, phenols, or water has been developed. This strategy provides a wide range of substrates and represents a simple process for the preparation of different imidazole derivatives in good yields with high regioselectivities.

Publisher URL: http://dx.doi.org/10.1021/acs.joc.7b01781

DOI: 10.1021/acs.joc.7b01781

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