3 years ago

Gold-Triggered Uncaging Chemistry in Living Systems

Gold-Triggered Uncaging Chemistry in Living Systems
Guy C. Lloyd-Jones, Thomas L. Bray, Jesús Santamaría, Lloyd Hamilton, Belén Rubio-Ruiz, Dirk Sieger, Silvia Irusta, Catherine Adam, Asier Unciti-Broceta, Ana M. Pérez-López, Víctor Sebastián, Paul M. Brennan
Bioorthogonal uncaging of a structurally diverse selection of cytotoxic precursors is achieved by heterogeneous gold catalysis, allowing safe activation of therapeutics by nonbiological chemical stimuli. In their Communication (DOI: 10.1002/anie.201705609), J. Santamaría and A. Unciti-Broceta et al. report gold-catalyzed bioorthogonal uncaging of clinically approved anticancer drugs in cancer cell culture, and the first intracranial activation of a bioorthogonal probe in a zebrafish.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/anie.201708379

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