Accounts of Chemical Research
Accounts of Chemical Research
5 years ago

Miniprotein Design: Past, Present, and Prospects

Miniprotein Design: Past, Present, and Prospects
Gail J. Bartlett, Emily G. Baker, Derek N. Woolfson, Kathryn L. Porter Goff
The design and study of miniproteins, that is, polypeptide chains <40 amino acids in length that adopt defined and stable 3D structures, is resurgent. Miniproteins offer possibilities for reducing the complexity of larger proteins and so present new routes to studying sequence-to-structure and sequence-to-stability relationships in proteins generally. They also provide modules for protein design by pieces and, with this, prospects for building more-complex or even entirely new protein structures. In addition, miniproteins are useful scaffolds for templating functional domains, for example, those involved in protein–protein interactions, catalysis, and biomolecular binding, leading to potential applications in biotechnology and medicine.

Publisher URL: http://dx.doi.org/10.1021/acs.accounts.7b00186

DOI: 10.1021/acs.accounts.7b00186

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