4 years ago

Bacillus subtilis Lipid Extract, A Branched-Chain Fatty Acid Model Membrane

Bacillus subtilis Lipid Extract, A Branched-Chain Fatty Acid Model Membrane
Sneha Chatterjee, Dean A. A. Myles, Piotr Zolnierczuk, Jonathan D. Nickels, Christopher B. Stanley, Barmak Mostofian, Michael Ohl, Robert F. Standaert, James G. Elkins, Roland Schulz, John Katsaras, Xiaolin Cheng
Lipid extracts are an excellent choice of model biomembrane; however at present, there are no commercially available lipid extracts or computational models that mimic microbial membranes containing the branched-chain fatty acids found in many pathogenic and industrially relevant bacteria. We advance the extract of Bacillus subtilis as a standard model for these diverse systems, providing a detailed experimental description and equilibrated atomistic bilayer model included as Supporting Information to this Letter and at (http://cmb.ornl.gov/members/cheng). The development and validation of this model represents an advance that enables more realistic simulations and experiments on bacterial membranes and reconstituted bacterial membrane proteins.

Publisher URL: http://dx.doi.org/10.1021/acs.jpclett.7b01877

DOI: 10.1021/acs.jpclett.7b01877

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