3 years ago

Syndecan-1 controls lung tumorigenesis by regulating microRNAs packaged in exosomes

Syndecan-1 is a transmembrane proteoglycan expressed prominently by lung epithelium and has pleiotropic functions such as regulating cell migration, proliferation, and survival. Loss of syndecan-1 expression by lung cancer cells is associated with higher-grade cancers and worse clinical prognosis. We evaluated the effect of syndecan-1 in various cell-based and animal models of lung cancer and found that lung tumorigenesis was moderated by syndecan-1. We also demonstrate that syndecan-1 (or lack thereof) altered the microRNA (miRNA) cargo carried within exosomes exported from lung cancer cells. Analysis of the changes in miRNA expression identified a distinct shift toward augmented pro-cancerous signaling, consistent with the changes found in lung adenocarcinoma. Collectively, our work identifies syndecan-1 as an important factor on lung cancer cells that shapes the tumor microenvironment through alterations in miRNA packaging within exosomes.

Publisher URL: www.sciencedirect.com/science

DOI: S0002944017306788

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