3 years ago

Recent updates for designing CCR5 antagonists as anti-retroviral agents

Recent updates for designing CCR5 antagonists as anti-retroviral agents
The healthcare system faces various challenges in human immunodeficiency virus (HIV) therapy due to resistance over Anti-Retroviral Therapy (ART) as a consequence of the evolutionary process. Despite the success of antiretroviral drugs like Zidovudine, Zalcitabine, Raltegravir WHO ranks HIV as one of the deadliest disease with a mortality of one million lives in 2016. Thus, there emerges an urgency of developing a novel anti-retroviral agents that combats resistant HIV strains. The clinical development of ART from a single drug regimen to current triple drug combination is very slow. The progression in the structural biology of the viral envelope prompted the discovery of novel targets, which can be demonstrated a proficient approach for drug design of anti-retroviral agents. The current review enlightens the recent updates in the structural biology of the viral envelope and focuses over CCR5 as a validated target as well as ways to overcome CCR5 resistance. The article also throws light on the recent trends and techniques for designing CCR5 antagonists that can combat HIV-1 infection. To conclude, the paper lists diversified scaffolds that are in pipeline by various pharmaceutical companies that could provide an aid for developing novel CCR5 antagonists.

Publisher URL: www.sciencedirect.com/science

DOI: S0223523418301077

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