Journal of the American Heart Association
Journal of the American Heart Association
5 years ago

Inhibition of 5-Hydroxytryptamine Receptor 2B Reduced Vascular Restenosis and Mitigated the β-Arrestin2-Mammalian Target of Rapamycin/p70S6K Pathway.

Yan Liu, Man Zhang, Qingbo Xu, Zhipeng Wang, Mo Wang, Yiqian Ban, Yahan Liu, Beilei Zhao, Guangmei Mao, Nanping Wang, Jing Li, Qiang Shen
As a monoamine neurotransmitter, 5-hydroxytryptamine (5-HT) or serotonin modulates mood, appetite, and sleep. Besides, 5-HT also has important peripheral functions. 5-HT receptor 2B (5-HT2BR) plays a key role in cardiovascular diseases, such as pulmonary arterial hypertension and cardiac valve disease. Percutaneous intervention has been used to restore blood flow in occlusive vascular disease. However, restenosis remains a significant problem. Herein, we investigated the role of 5-HT2BR in neointimal hyperplasia, a key pathological process in restenosis.

Publisher URL: http://doi.org/10.1161/JAHA.117.006810

DOI: 10.1161/JAHA.117.006810

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