Plant Physiology
Plant Physiology
5 years ago

Synthetic microProteins: versatile tools for post-translational regulation of target proteins.

Vandasue Rodrigues, Sukwon Choi, Daniel Straub, Seong Wook Yang, Ulla Dolde, Kaushal Bhati, Stephan Wenkel
MicroProteins are small, single-domain proteins that can regulate multi-domain proteins by sequestering them into novel, often non-productive complexes. In the past years, several microProteins have been identified in plants and animals, most of which negatively regulate transcription factors. Novel microProtein candidates that potentially target a wide range of different protein classes, were recently identified in a computational approach. Here, we identify and classify all Arabidopsis microProteins and developed a synthetic microProtein approach to target specific protein classes, such as hydrolases, receptors and lyases in a proof-of-concept approach. Our findings reveal that microProteins can be used to influence different physiological processes which makes them useful tools for post-translational regulation in plants.

Publisher URL: http://doi.org/10.1104/pp.17.01743

DOI: 10.1104/pp.17.01743

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