ACS Applied Materials & Interfaces
ACS Applied Materials & Interfaces
5 years ago

Lysosome Enlargement Enhanced Photochemotherapy Using a Multifunctional Nanogel

Lysosome Enlargement Enhanced Photochemotherapy Using a Multifunctional Nanogel
Ching-Hsuan Tung, Weiqi Zhang
Large lysosomes are susceptible toward rupture because of an increased membrane tension. Here we report a strategy to first enlarge and weaken the lysosome and then destroy it to boost the efficiency of photochemotherapy using a hyaluronan nanogel, carrying chloroquine as a lysosomal expander, rhodamine B as a photosensitive lysosomal destroyer, and cisplatin as a chemotherapeutic. This all-in-one nanogel provides a facile approach and new insight into improve the photochemotherapy, by making use of lysosome’s size, as a risk factor in lysosomal destabilization.

Publisher URL: http://dx.doi.org/10.1021/acsami.7b16575

DOI: 10.1021/acsami.7b16575

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