Tetrahedron Letters
Tetrahedron Letters
5 years ago

A novel 10-membered macrocyclic lactone from the mangrove-derived endophytic fungus Annulohypoxylon sp.

A novel 10-membered macrocyclic lactone from the mangrove-derived endophytic fungus Annulohypoxylon sp.
A novel 10-membered macrolactone, hypoxylide (1), was isolated from the endophytic fungus Annulohypoxylon sp. that was obtained from the Mangrove plant Rhizophora racemosa. The structure and absolute configuration of 1 were unambiguously elucidated by comprehensive 1D and 2D NMR, as well as by HRESIMS and ECD spectroscopic analyses. Hypoxylide (1) features an unprecedented polyketide skeleton comprised of a trihydroxynaphthalene-dione moiety fused to a decalactone ring. A plausible biosynthetic pathway of this novel metabolite is proposed.

Publisher URL: www.sciencedirect.com/science

DOI: S0040403918300017

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