Journal of the American Chemical Society
Journal of the American Chemical Society
5 years ago

Directed Biofabrication of Nanoparticles through Regulating Extracellular Electron Transfer

Directed Biofabrication of Nanoparticles through Regulating Extracellular Electron Transfer
Nan-Qing Zhou, Long Zhang, Li-Jiao Tian, Han-Qing Yu, Gang Liu, Dong-Feng Liu, Yong Guan, Wei-Kang Wang, Wen-Wei Li, Ting-Ting Zhu, Yang-Chao Tian, Peng-Fei An, Jun-Cai Dong, Jie-Jie Chen
Biofabrication of nanomaterials is currently constrained by a low production efficiency and poor controllability on product quality compared to chemical synthetic routes. In this work, we show an attractive new biosynthesis system to break these limitations. A directed production of selenium-containing nanoparticles in Shewanella oneidensis MR-1 cells, with fine-tuned composition and subcellular synthetic location, was achieved by modifying the extracellular electron transfer chain. By taking advantage of its untapped intracellular detoxification and synthetic power, we obtained high-purity, uniform-sized cadmium selenide nanoparticles in the cytoplasm, with the production rates and fluorescent intensities far exceeding the state-of-the-art biosystems. These findings may fundamentally change our perception of nanomaterial biosynthesis process and lead to the development of fine-controllable nanoparticles biosynthesis technologies.

Publisher URL: http://dx.doi.org/10.1021/jacs.7b07460

DOI: 10.1021/jacs.7b07460

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