Organic Letters
Organic Letters
5 years ago

Genetic Manipulation of the COP9 Signalosome Subunit PfCsnE Leads to the Discovery of Pestaloficins in Pestalotiopsis fici

Genetic Manipulation of the COP9 Signalosome Subunit PfCsnE Leads to the Discovery of Pestaloficins in Pestalotiopsis fici
Hongwei Liu, Huixi Zou, Xingzhong Liu, Yongsheng Che, Yanjing Zheng, Wen-Bing Yin, Ling Liu, Ying Huang, Haining Lyu, Ke Ma
By deleting the COP9 signalosome subunit PfcsnE from Pestalotiopsis fici, seven compounds that were newly produced by the mutant could be characterized, including five new structures, pestaloficins A–E (1 and 3–6). Pestaloficin A (1) represents a new type of dimeric cyclohexanone derivative linked through an unprecedented pentacyclic spiral ring.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b02346

DOI: 10.1021/acs.orglett.7b02346

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