Bioorganic and Medicinal Chemistry
Bioorganic and Medicinal Chemistry
5 years ago

Sequence-specific DNA Binding Pyrrole–Imidazole Polyamides and Their Applications

Sequence-specific DNA Binding Pyrrole–Imidazole Polyamides and Their Applications
Pyrrole–imidazole polyamides (Py–Im polyamides) are cell-permeable compounds that bind to the minor groove of double-stranded DNA in a sequence-specific manner without causing denaturation of the DNA. These compounds can be used to control gene expression and to stain specific sequences in cells. Here, we review the history, structural variations, and functional investigations of Py–Im polyamides.

Publisher URL: www.sciencedirect.com/science

DOI: S0968089617324987

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