4 years ago

Rational Design of GO-Modified Fe3O4/SiO2 Nanoparticles with Combined Rhenium-188 and Gambogic Acid for Magnetic Target Therapy

Rational Design of GO-Modified Fe3O4/SiO2 Nanoparticles with Combined Rhenium-188 and Gambogic Acid for Magnetic Target Therapy
Hongming Yuan, Chaoying Ni, Yuxiang Yang, Haowei Shi, Huan Yang, Chao Cheng, Yicheng Liu
Peanutlike magnetic-fluorescent Fe3O4/SiO2 nanoparticles, with an effective dynamic diameter of 180 nm, were synthesized via EuO+ doping and coupling of two Fe3O4 cores and reassembling through the solvothermal process. Spherical pure Fe3O4/SiO2 nanoparticles with an effective dynamic diameter of 230 nm were also prepared for comparison. We designed graphene oxide (GO)-modified core–shell Fe3O4/SiO2 nanoparticles as a nanocarrier for loading gambogic acid (GA) following labeling with radioisotope rhenium-188. We also performed GA loading and releasing on GA-loaded magnetic nanoparticles, in vivo biodistribution, and magnetic drug targeting therapy experiments. Results indicated that the GA-loaded magnetic nanoparticles demonstrate a clear pH-dependent drug release behavior, having a higher release rate in acidic environments. The in vivo biodistribution of the magnetic nanoparticles has morphologic dependency, and the peanutlike nanoparticles (PN-Fe3O4) tend to accumulate more in the spleen, lung, and liver than in the spherical nanoparticles (S-Fe3O4). The targeted therapy showed a higher efficacy of PN-Fe3O4 in inhibiting tumor cell growth than the nontargeted therapy. The polyethyleneimine (PEI) grafting of PN-Fe3O4 with amide bond was also designed to find an effective active targeting antitumor agent considering the fact that the PEI–GO conjugate has a higher GA load efficiency and the convergence effect.

Publisher URL: http://dx.doi.org/10.1021/acsami.7b07589

DOI: 10.1021/acsami.7b07589

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