3 years ago

Controlled Zn2+-Triggered Drug Release by Preferred Coordination of Open Active Sites within Functionalization Indium Metal Organic Frameworks

Controlled Zn2+-Triggered Drug Release by Preferred Coordination of Open Active Sites within Functionalization Indium Metal Organic Frameworks
Ruiqing Fan, Kai Xing, Liangsheng Qiang, Xinya Ran, Haoxin Ye, Xi Du, Ping Wang, Yang Song, Yulin Yang
Drug delivery in target regions could make extraordinary progress in chemoselective therapies. A novel preferred coordination (PC) strategy referring to proactive interacting with open active sites to replace previous occupation by ion-exchange for controlling release of drug molecules is well-constructed. Two topological types of MOF-In1 (Schläfli symbol: (4,8)-connected of (410·615·83)(45·6)2) and MOF-In2 (Schläfli symbol: (4,4)-connected of (66)) show the specific way. Increasing node connectivity as well as the trapping of guest OH anions, 5-fluorouracil (5-FU) is preferentially captured into the MOF-In1, which exhibits an outstanding loading capacity around 34.32 wt %. 19F NMR spectroscopy was further employed to investigate host–guest interaction and reveal the binding constant (Ka = 3.84 × 102 M–1). Meanwhile, the controlled release of 5-FU in a simulated human body with liquid phosphate-buffered saline solution by biofriendly Zn2+-triggered is realized. With an elevated Zn2+ concentration, the drug release will be enhanced. This efficient strategy for MOFs as multifunctional drug carrier opens a new avenue for biological and medical applications.

Publisher URL: http://dx.doi.org/10.1021/acsami.7b09227

DOI: 10.1021/acsami.7b09227

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