Organic Letters
Organic Letters
5 years ago

Synthesis of N,N-Dioxopyridazines

Synthesis of N,N-Dioxopyridazines
Shlomo Rozen, Avshalom Shaffer
Despite many efforts, one of the smallest heterocycles containing two nitrogen atoms, pyridazine, could not be converted to its N,N-dioxide (see, however, Nakadate et al. Chem. Pharm. Bull. 1970, 18, 1211–1218). HOF·CH3CN, made easily from diluted fluorine, was able to accomplish this task in a fast reaction with good yields.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b02310

DOI: 10.1021/acs.orglett.7b02310

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