3 years ago

A gadolinium(III)-coumarin complex based MRI/Fluorescence bimodal probe for the detection of fluoride ion in aqueous medium

A gadolinium(III)-coumarin complex based MRI/Fluorescence bimodal probe for the detection of fluoride ion in aqueous medium
By virtue of high affinity of Gadolinium(III) with fluoride, a novel MRI/fluorescence bimodal probe was prepared by self-assembly of Gd(III) based contrast agent with the coumarin-based fluorophore (CL). Upon addition of fluoride ion (F) to the aqueous solution of EDTA-Gd(III)-CL, the replacement of coordination CL occurs, realizing switch-on both the longitudinal relaxivity (r 1) and fluorescence responses, simultaneously. The fluorescence detection limit for fluoride ions was established at 0.15 μM. EDTA-Gd(III)-CL features of favorable selectivity towards F for both relaxivity and fluorescence, reliability at physiological pH allow its potential application in biomedical diagnosis fields.

Publisher URL: www.sciencedirect.com/science

DOI: S004040201730827X

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