Tetrahedron
Tetrahedron
5 years ago

The total synthesis of (±)-sanggenol F

The total synthesis of (±)-sanggenol F
A concise and efficient total synthesis of sanggenol F (1) in racemic form has been completed via a sequence of 15 steps with an overall yield of 3.1%, starting from commercially available 2,4,6-trihydroxyacetophenone. Meanwhile, a semisynthesis of sanggenol F racemate has also been achieved in 11.1% overall yield via 7 steps with naturally-occurring morin (2) as the starting material. One step and a stepwise approach were employed to construct the two prenyl side chains at 2- and 6-positions by Claisen rearrangement reaction.

Publisher URL: www.sciencedirect.com/science

DOI: S004040201730488X

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