Organic Letters
Organic Letters
5 years ago

Utilization of MeOH as a C1 Building Block in Tandem Three-Component Coupling Reaction

Utilization of MeOH as a C1 Building Block in Tandem Three-Component Coupling Reaction
Milan Maji, Sabuj Kundu, Dibyajyoti Panja, Gourab Kanti Das, Sujan Shee, Kaushik Chakrabarti, Bhaskar Paul
Ru(II) catalyzed tandem synthesis of α-branched methylated ketones via multicomponent reactions following the hydrogen borrowing process is described. This nonphosphine-based air and moisture stable catalyst efficiently produced various methylated ketones using methanol as a methylating agent. This system was found to be highly effective in three-component coupling between methanol, primary alcohols, and methyl ketones. A proposed catalytic cycle for the α-methylation is supported by DFT calculations as well as kinetic experiments.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b02105

DOI: 10.1021/acs.orglett.7b02105

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