Molecular Pharmaceutics
Molecular Pharmaceutics
5 years ago

Gellan Nanohydrogels: Novel Nanodelivery Systems for Cutaneous Administration of Piroxicam

Gellan Nanohydrogels: Novel Nanodelivery Systems for Cutaneous Administration of Piroxicam
Patrizia Procacci, Nicole Zoratto, Chiara Di Meo, Pietro Matricardi, Silvia Franzé, Umberto M. Musazzi, Claudia Cencetti, Francesco Cilurzo
The feasibility to use gellan nanohydrogels (Ge-NH) as delivery system for the cutaneous administration of piroxicam (PRX) was investigated using gellan conjugated with cholesterol or riboflavin. The in vitro skin penetration studies through human epidermis were performed using a saturated aqueous drug solution, a 50% w/v Transcutol® aqueous solution and a commercially available PRX plaster as controls. Confocal microscopy, ATR-FTIR spectroscopy, circular dichroism and a dynamometer assisted extrusion assay were performed to clarify the permeation mechanism of Ge-NHs. The skin permeation studies evidenced that Ge-NHs enhance the PRX retention in the epidermis and, at the same time, slow down the permeation process with respect to the controls. NHs can penetrate the stratum corneum, and then gradually disassemble thus diffusing in the viable epidermis reaching the spinosum layer. In conclusion, NHs represent a novel strategy to target poorly permeable compounds in the epidermis, thus improving the management of cutaneous pathologies.

Publisher URL: http://dx.doi.org/10.1021/acs.molpharmaceut.7b00926

DOI: 10.1021/acs.molpharmaceut.7b00926

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.