4 years ago

Releasable and traceless PEGylation of arginine-rich antimicrobial peptides

Releasable and traceless PEGylation of arginine-rich antimicrobial peptides
D. Andina, M. A. Gauthier, S. Nahar, J.-C. Leroux, Y. Gong
This study reports a strategy to temporarily mask arginine residues within antimicrobial peptides (AMPs) with methoxy poly(ethylene glycol) (mPEG). PEGylation protects AMPs from serum proteases, and can be released at a pharmaceutically-relevant rate. Fully active and unmodified (i.e., native) AMPs are released with time.

Publisher URL: http://feeds.rsc.org/~r/rss/SC/~3/hcfMTyMiTb8/C7SC00770A

DOI: 2017/SC/C7SC00770A

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