Annals of Neurology
Annals of Neurology
5 years ago

Sleep and Cognitive Decline: A Prospective Non-demented Elderly Cohort Study

Shin Gyeom Kim, Kyung Phil Kwak, Ju Ri Lee, Dong Woo Lee, Jong Chul Youn, Jin Hyeong Jhoo, Jong Woo Hong, Jung Jae Lee, Jeong Lan Kim, Kyoung Hwan Lee, Bong-Jo Kim, Seung-Ho Ryu, Seung Wan Suh, Seok Bum Lee, Dong Young Lee, Guehee Han, Sang Hoon Oh, Seok Woo Moon, Jiyeong Seo, Ki Woong Kim, Ji Won Han, Tae Hui Kim, Soon Jai Kwon, Joon Hyuk Park, Seonjeong Byun
Objective: To investigate sleep disturbances that induce cognitive changes over four years in non-demented elderlies. Methods: Data were acquired from a nationwide, population-based, prospective cohort of Korean elderlies (2,238 normal cognition [NC] and 655 mild cognitive impairment [MCI]). At baseline and 4-year follow up assessments, sleep-related parameters (mid-sleep time, sleep duration, latency, subjective quality, efficiency and daytime dysfunction) and cognitive status were measured using Pittsburgh Sleep Quality Index and Consortium to Establish a Registry for Alzheimer's Disease Assessment, respectively. We used logistic regression models adjusted for covariates including age, sex, education, apolipoprotein E genotype, Geriatric Depression Scale, Cumulative Illness Rating Scale, and physical activity. Results: In participants with NC, long sleep latency (> 30 min), long sleep duration (≥ 7.95 hr), and late mid-sleep time (after 3:00AM) at baseline were related to the risk of cognitive decline at 4-year follow-up assessment; odds ratio (OR) was 1.40 for long sleep latency, 1.67 for long sleep duration, and 0.61 for late mid-sleep time. These relationships remained significant when these variables maintained their status throughout the follow-up period. Newly developed long sleep latency also doubled the risk of cognitive decline. In those with MCI, however, only long sleep latency reduced the chance of reversion to NC (OR = 0.69). Interpretation: As early markers of cognitive decline, long sleep latency can be used for elderlies with NC or MCI, while long sleep duration and relatively early sleep time might be used for cognitively normal elderlies only. This article is protected by copyright. All rights reserved.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/ana.25166

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