5 years ago

A polyaromatic nanocapsule as a sucrose receptor in water

Michito Yoshizawa, Taisuke Hasegawa, Munetaka Akita, Masahiro Yamashina, Shigehiko Hayashi

Selective recognition of saccharides by artificial receptors in water is a challenging goal due to their strong hydrophilicities and complex molecular structures with subtle regio- and stereochemical differences. We report the selective and efficient encapsulation of d-sucrose within a coordination-driven molecular capsule from natural saccharide mixtures in water (~100% selectivity, >85% yield, and ~103 M–1 binding constant). Unlike previous artificial receptors and natural receptors that rely on multiple hydrogen-bonding interactions, theoretical calculations and control experiments indicate that the observed unique selectivity arises from multiple CH- interactions between the sucrose hydrocarbon backbone and the shape-complementary polyaromatic cavity (~1 nm in diameter) of the capsule.

Publisher URL: http://advances.sciencemag.org/cgi/content/short/3/8/e1701126

DOI: 10.1126/sciadv.1701126

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