Journal of Organic Chemistry
Journal of Organic Chemistry
5 years ago

Palladium-Catalyzed Cascade Assembly of Tricyclic Spiroethers from Diene-Alcohol Precursors

Palladium-Catalyzed Cascade Assembly of Tricyclic Spiroethers from Diene-Alcohol Precursors
David Lankri, Yelena Mostinski, Dmitry Tsvelikhovsky
Palladium-catalyzed carboetherification-Heck reactions to form tricyclic spiroethers, which are frequently observed as scaffold segments of various biochemical compounds, from simple diene-alcohols have been carried out in a cascade fashion. This is the first attempt to link simple alcohols with diverse, medium-sized spiroether architectures. The reported synthetic strategy is short and robust and offers rapid delivery of a broad spectrum of tricyclic spiranoid ethers.

Publisher URL: http://dx.doi.org/10.1021/acs.joc.7b01481

DOI: 10.1021/acs.joc.7b01481

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