5 years ago

One-Pot Synthesis of Unsymmetric Diaryliodonium Salts from Iodine and Arenes

One-Pot Synthesis of Unsymmetric Diaryliodonium Salts from Iodine and Arenes
Marcus Reitti, Erik Lindstedt, Berit Olofsson
The first synthesis of unsymmetric diaryliodonium salts directly from iodine and arenes is presented. The methodology provides diaryliodonium salts with the trimethoxyphenyl (TMP) moiety as dummy group. The protocol avoids the customary use of iodoarenes, which can be both expensive and toxic. Excess reagents are not required, and the reactions are performed under mild conditions. O-Arylations with these TMP salts were demonstrated to be highly chemoselective.

Publisher URL: http://dx.doi.org/10.1021/acs.joc.7b01652

DOI: 10.1021/acs.joc.7b01652

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