3 years ago

Stereoselective Synthesis of Trisubstituted Alkenes via Cobalt-Catalyzed Double Dehydrogenative Borylations of 1-Alkenes

Stereoselective Synthesis of Trisubstituted Alkenes via Cobalt-Catalyzed Double Dehydrogenative Borylations of 1-Alkenes
Lei Zhang, Zheng Huang, Guixia Liu, Suzhen Zhu, Huanan Wen
A highly selective cobalt-catalyzed single and double dehydrogenative borylations (DHBs) of terminal alkenes have been developed for the synthesis of trans-monoborylalkenes and diborylalkenes, respectively. While the cobalt-catalyzed double DHBs of aryl 1-alkenes with 2 equiv of bis(pinacolato)diboron (B2pin2) in the presence of 1 equiv of CsF in DMF produce 1,1-diborylalkenes selectively, the double DHBs with alkyl 1-alkenes generate cis-1,2-diborylalkenes in a selective manner. The 1,1-diborylalkene products are further applied to stepwise and stereospecific cross-couplings with aryl halides to create trisubstituted alkenes, including triaryl alkenes.

Publisher URL: http://dx.doi.org/10.1021/acscatal.7b02104

DOI: 10.1021/acscatal.7b02104

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.