5 years ago

Self-Ordering Secondary Structure of d- and l-Arginine-Derived Polyamidoamino Acids

Self-Ordering Secondary Structure of d- and l-Arginine-Derived Polyamidoamino Acids
Paolo Ferruti, Elisabetta Ranucci, Alessio Terenzi, Amedea Manfredi, Giuseppina Raffaini, Fabio Ganazzoli, Jenny Alongi, Federica Lazzari, Nicolò Mauro
This paper reports on synthesis, acid–base properties and pH-dependent structuring in water of d-, l- and d,l-ARGO7, bioinspired polymers obtained by polyaddition of the corresponding arginine stereoisomers with N,N′-methylenebis(acrylamide). The circular dichroism spectra of d- and l-ARGO7 showed a peak at 228 nm and quickly and reversibly responded to pH changes, but were nearly unaffected by temperature, ionic strength, and denaturating agents. Theoretical modeling studies of L-ARGO7 showed that it assumed a folded structure. Intramolecular interactions led to transoid arrangements of the main chain reminiscent of the protein hairpin motif. Torsion angles showed a quite similar distribution at pH 6 and 14 consistent with the similarity of the CD spectra from pH 6 upward.

Publisher URL: http://dx.doi.org/10.1021/acsmacrolett.7b00492

DOI: 10.1021/acsmacrolett.7b00492

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