Journal of Organic Chemistry
Journal of Organic Chemistry
5 years ago

Syntheses of 4-(Heteroaryl)cyclohexanones via Palladium-Catalyzed Ester α-Arylation and Decarboxylation

Syntheses of 4-(Heteroaryl)cyclohexanones via Palladium-Catalyzed Ester α-Arylation and Decarboxylation
Sisi Zhang, Siqian Liu, Su Xu, Qun Jiang, Jianguang Zhou, Peng Fu, Qi Zhang
An alternative synthesis of 4-(heteroaryl)cyclohexanones is described featuring a palladium-catalyzed ester α-arylation followed by decarboxylation. The substrate scope is broad with a wide range of heteroaryl halides. In particular, the reaction robustness is demonstrated by the synthesis of >10 g of 4-(pyrazin-2-yl)cyclohexanone with 85% overall yield.

Publisher URL: http://dx.doi.org/10.1021/acs.joc.7b01443

DOI: 10.1021/acs.joc.7b01443

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