5 years ago

Direct Electrical Stimulation in the Human Brain Disrupts Melody Processing

Direct Electrical Stimulation in the Human Brain Disrupts Melody Processing
Elizabeth Marvin, Bradford Z. Mahon, Alexander Teghipco, Bram Diamond, Lynn Liu, Raouf Belkhir, Benjamin L. Chernoff, Samuel B. Tomlinson, John Langfitt, Webster H. Pilcher, Wesley Lewis, Maxwell H. Sims, Jonathan Stone, Steve Erickson, Sarah B. Gannon, Trenton Tollefson, Susan O. Smith, Frank E. Garcea


Prior research using functional magnetic resonance imaging (fMRI) [1–4] and behavioral studies of patients with acquired or congenital amusia [5–8] suggest that the right posterior superior temporal gyrus (STG) in the human brain is specialized for aspects of music processing (for review, see [9–12]). Intracranial electrical brain stimulation in awake neurosurgery patients is a powerful means to determine the computations supported by specific brain regions and networks [13–21] because it provides reversible causal evidence with high spatial resolution (for review, see [22, 23]). Prior intracranial stimulation or cortical cooling studies have investigated musical abilities related to reading music scores [13, 14] and singing familiar songs [24, 25]. However, individuals with amusia (congenitally, or from a brain injury) have difficulty humming melodies but can be spared for singing familiar songs with familiar lyrics [26]. Here we report a detailed study of a musician with a low-grade tumor in the right temporal lobe. Functional MRI was used pre-operatively to localize music processing to the right STG, and the patient subsequently underwent awake intraoperative mapping using direct electrical stimulation during a melody repetition task. Stimulation of the right STG induced "music arrest" and errors in pitch but did not affect language processing. These findings provide causal evidence for the functional segregation of music and language processing in the human brain and confirm a specific role of the right STG in melody processing.

Video Abstract

Publisher URL: http://www.cell.com/current-biology/fulltext/S0960-9822(17)30955-7

DOI: 10.1016/j.cub.2017.07.051

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.