Cancer Biology: APC Delivers Kiss of Death to Focal Adhesions
Summary
New work shows that the actin-nucleating ability of the adenomatous polyposis coli protein is required for disassembly of focal adhesions. Loss of this function in Apc mutant cells reduces directed cell migration, potentially explaining the decreased migration of colon cancer cells.
Publisher URL: http://www.cell.com/current-biology/fulltext/S0960-9822(17)30887-4
DOI: 10.1016/j.cub.2017.07.028
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