3 years ago

G-Quadruplexes: Prediction, Characterization, and Biological Application

G-Quadruplexes: Prediction, Characterization, and Biological Application
Catherine J. Merrick, Chun Kit Kwok

Guanine (G)-rich sequences in nucleic acids can assemble into G-quadruplex structures that involve G-quartets linked by loop nucleotides. The structural and topological diversity of G-quadruplexes have attracted great attention for decades. Recent methodological advances have advanced the identification and characterization of G-quadruplexes in vivo as well as in vitro, and at a much higher resolution and throughput, which has greatly expanded our current understanding of G-quadruplex structure and function. Accumulating knowledge about the structural properties of G-quadruplexes has helped to design and develop a repertoire of molecular and chemical tools for biological applications. This review highlights how these exciting methods and findings have opened new doors to investigate the potential functions and applications of G-quadruplexes in basic and applied biosciences.

Publisher URL: http://www.cell.com/trends/biotechnology/fulltext/S0167-7799(17)30161-0

DOI: 10.1016/j.tibtech.2017.06.012

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