Tetrahedron Letters
Tetrahedron Letters
5 years ago

Iron-catalyzed cross-dehydrogenative CN coupling of thiohydantoins with various amines

Iron-catalyzed cross-dehydrogenative CN coupling of thiohydantoins with various amines
A novel iron-catalyzed CN bond construction method for the hetero-cross-dehydrogenative coupling (CDC) of diverse thiohydantoins with amines utilizing TBHP as the oxidant was developed. This sp3 CH amination at the carbons alpha to carbonyl groups of thiohydantoin tolerates the presence of a wide range of functional groups and provides the corresponding N-substituted amines in moderate to good yields. Various substrate scopes and optimum reaction conditions leads inside in organic synthesis.

Publisher URL: www.sciencedirect.com/science

DOI: S0040403918300364

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