Journal of Organic Chemistry
Journal of Organic Chemistry
5 years ago

Cascade One-Pot Method To Synthesize Isoquinolin-1(2H)-ones with α-Bromo Ketones and Benzamides via Pd-catalyzed C–H Activation

Cascade One-Pot Method To Synthesize Isoquinolin-1(2H)-ones with α-Bromo Ketones and Benzamides via Pd-catalyzed C–H Activation
Chen Ma, Caixia Xie, Yadi Niu, Zhen Dai
A cross-coupling strategy of palladium-catalyzed ortho-C–H bond activation and intramolecular addition of N–C annulation to synthesize isoquinolin-1(2H)-ones has been developed. A wide range of α-bromo ketones with different substituents proceeded smoothly in this reaction, and varieties of isoquinolin-1(2H)-one derivatives were obtained in moderate to good yields.

Publisher URL: http://dx.doi.org/10.1021/acs.joc.7b03224

DOI: 10.1021/acs.joc.7b03224

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